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姓 名： | 温聪颖 |
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职 称： | 副教授 | |||||
导师类别： | 博士生导师 | |||||
系 室： | 化学系 | |||||
研究领域： | 分析化学，纳米生物检测 | |||||
电子邮箱： | flcyxt@163.com | |||||
◎教育背景 | ||||||
2004.9—2008.7，西南大学437ccm必赢国际，化学学士 2008.9—2014.7，武汉大学化学与分子科学学院，分析化学博士 | ||||||
◎工作经历 | ||||||
2014.7—2018.12，437ccm必赢国际，理学院化学系，讲师 2019.1—2021.12，437ccm必赢国际，理学院化学系，副教授 2022.1—今 437ccm必赢国际，437ccm必赢国际化学系，副教授 | ||||||
◎研究方向 | ||||||
[1] 荧光量子点、磁性纳米颗粒、贵金属纳米粒子的制备 [2] 纳米生物探针的构建 [3] 细菌、病毒、肿瘤细胞等的快速灵敏检测 | ||||||
◎科研项目 | ||||||
[1] 多功能纳米材料在水环境病原体多模式高通量侧流层析检测中的应用研究，国家自然科学基金面上项目，2024.01-2027.12，主持； [2] 荧光/磁性纳米球用于循环肿瘤细胞的高灵敏检测，国家自然科学基金青年基金， 2016.01-2018.12，主持； [3] 基于多靶标识别捕获循环肿瘤细胞用于癌症诊断和预后研究，山东省自然科学基金面上项目，2021.01-2023.12，主持； [4] 基于磁富集和荧光编码技术的多种肿瘤标志物的快速同时检测，山东省中青年科学家奖励基金， 2015.07-2017.07，主持； [5] 基于磁性/荧光纳米材料的多种肿瘤标志物联合检测试剂盒的研发，青岛市应用基础研究项目，2017.03-2019.03，主持； [6] 基于光磁纳米材料的传染病病原体现场即时检测技术的研发，央高校基本科研业务费专项基金， 2022.01-2024.12，主持； [7] 基于量子点或磁性纳米粒子的复合材料在蛋白质分析中的应用研究，中央高校基本科研业务费专项基金， 2015.01-2016.12，主持； [8] 基于量子点和磁性纳米粒子的荧光/磁性纳米球的制备，中国石油大学人才引进基金， 2015.01-2017.12，主持； [9] 荧光/磁性纳米球用于多种肿瘤标志物的快速灵敏联合检测，湖北省重点实验室开放课题，2017.01-2017.12，主持； [10]“需求定制式”化学综合实验课程建设与实践，437ccm必赢国际教学改革项目， 2018.04-2020.04，主持； [11] 需求定制式”化学综合实验课程建设与实践，437ccm必赢国际教学改革项目， 2018.04-2020.04，主持； [12] 科产教融合下的《现代分析技术》课程建设与实践，437ccm必赢国际教学改革项目， 2022.11-2024.11，主持。 | ||||||
◎代表性论文及专利 | ||||||
1.论文 [1] Kun Wang, Xiaohui Liu, Xinyi Liang, Yongzhong Jiang, Cong-Ying Wen*, Jingbin Zeng*. Near-Infrared Responsive Ag@Au Nanoplates with Exceptional Stability for Highly Sensitive Colorimetric and Photothermal Dual-Mode Lateral Flow Immunoassay. Analytical Chemistry,2024,96, 3208-3216. [2] Xiang Li, Dong Yu, Huiwen Li, Ruichang Sun, Zhuoran Zhang, Tianyu Zhao, Gengchen Guo, Jing-Bin Zeng*, Cong-Ying Wen*, High-density Au nanoshells assembled onto Fe3O4 nanoclusters for integrated enrichment and photothermal/colorimetric dual-mode detection of SARS-CoV-2 nucleocapsid protein. Biosens. Bioelectron. 2023, 241, 115688. [3] Cong-Ying Wen, Xinyi Liang, Jianting Liu, Tian-Yu Zhao, Xiang Li, Yu Zhang, Gengchen Guo, Zhuoran Zhang, and Jingbin Zeng*. An achromatic colorimetric nanosensor for sensitive multiple pathogen detection by coupling plasmonic nanoparticles with magnetic separation. Talanta 2023, 256, 124271. [4] Kun Wang, Dong Yu, Xinyi Liang, Wenqi Lu, Xuan Jiang, Khurshid Tashpulatov, Zeng Jingbin, Cong-Ying Wen *. Janus Fe3O4-Au@Pt nanozymes based lateral flow assay for enhanced-sensitive colorimetric detection of influenza A virus. Microchemical Journal 2024, 204, 111104. [5] Cong-Ying Wen*, Ling-Jin Zhao, Ying Wang, Kun Wang, Hui-Wen Li, Xiang Li, Min Zi and Jing-Bin Zeng*. Colorimetric and photothermal dual-mode lateral flow immunoassay based on Au-Fe3O4 multifunctional nanoparticles for detection of Salmonella typhimurium. Microchimica Acta 2023, 190 (2), 57. [6] Penghui Liang, Qi Guo, Tianyu Zhao, Cong-Ying Wen*, Zhangyu Tian, Yanxue Shang, Jinyan Xing, Yongzhong Jiang, Jingbin Zeng*. Ag Nanoparticles with Ultrathin Au Shell-Based Lateral Flow Immunoassay for Colorimetric and SERS Dual-Mode Detection of SARS-CoV-2 IgG, Analytical Chemistry, 2022, 94, 8466-8473. [7] Yu Zhang, Mingfu Gong, Xiang Li, Hongyu Liu, Penghui Liang, Shuhua Cui, Liang Zhang, Chunyu Zhou, Tao Sun, Maosheng Zhang, Cong-Ying Wen*, Zeng Jingbin*. Au-Fe3O4 heterodimer multifunctional nanoparticles-based platform for ultrasensitive naked-eye detection of Salmonella typhimurium, Journal of Hazardous Materials, 2022, 436. [8] Tianyu Zhao, Penghui Liang, Jiaqi Ren, Jinyue Zhu, Xianning Yang, Hongyu Bian, Jingwen Li, Xiaofeng Cui, Chunhui Fu, Jinyan Xing*, Congying Wen*, Jingbin Zeng*. Gold-silver alloy hollow nanoshells-based lateral flow immunoassay for colorimetric, photothermal, and SERS tri-mode detection of SARS-CoV-2 neutralizing antibody. Analytica Chimica Acta, 2023, 1255, 341102. [9] Jingwen Li, Penghui Liang, Tianyu Zhao, Gengchen Guo, Jinyue Zhu, Congying Wen*, Jingbin Zeng*. Colorimetric and Raman dual-mode lateral flow immunoassay detection of SARS-CoV-2 N protein antibody based on Ag nanoparticles with ultrathin Au shell assembled onto Fe(3)O(4) nanoparticles. Analytical and Bioanalytical Chemistry, 2023, 415 (4), 545-554. [10]Yu Zhang, Yu‑Long Li, Shu‑Hua Cui, Cong‑Ying Wen*, Peng Li, Jian‑Feng Yu, Shi‑Ming Tang, Jing‑Bin Zeng*. Distance-Based Detection of Ag+ with Gold Nanoparticles-Coated Microfluidic Paper. Journal of Analysis and Testing, 2021, 5, 11-18. [11]Yongzhen Dong, Cong-Ying Wen (共第一), Yongxin She, Yu Zhang, Yiping Chen,* Jingbin Zeng*, Magnetic Relaxation Switching Immunoassay Based on Hydrogen Peroxide-Mediated Assembly of Ag@Au-Fe3O4 Nanoprobe for Detection of Aflatoxin B1. Small 2021, e2104596. [12]Cong-Ying Wen, Yu Chen, Rongsheng Liu, Jiankun Huang, Dawei Wang*, Zejun Cao, Benjamin Meteku, Jing-Bin Zeng*, Matrix colorimetry for high-resolution visual detection of free cyanide with Au@Au–Ag yolk–shell nanoparticles. Journal of Materials Chemistry C 2021,9 (13), 4661-4669. [13]Yu Zhang, Shu‑Hua Cui, Cong‑Ying Wen*, Peng Li, Jian‑Feng Yu, Shi‑Ming Tang, Jing‑Bin Zeng*, Distance-Based Detection of Ag+ with Gold Nanoparticles-Coated Microfluidic Paper. Journal of Analysis and Testing 2021, 5, 11-18. [14]Cong-Ying Wen*, Ting-Ting Liu, Ling-Ling Wu, Yi-Min Li, Jia-Yi Sun and Jing-Bin Zeng*, Magnetic nanospheres for convenient and efficient capture and release of hepatitis B virus DNA. Talanta 2019, 197, 605-611. [15]Jian Zhang,Cong-Ying Wen (共第一), Qing Li, Benjamin Edem Meteku, Rusong Zhao, Bingwen Cui, Xiyou Li and Jingbin Zeng*, Electro-enhanced solid-phase microextraction of bisphenol A from thermal papers using a three-dimensional graphene coated fiber. J. Chromatogr. A 2019, 1585, 27-33. [16]Cong-Ying Wen*, Jia-Hui Bi, Ling-Ling Wu, Jing-Bin Zeng*, Aptamer-functionalized magnetic and fluorescent nanospheres for one-step sensitive detection of thrombin. Microchimica Acta 2018, 185 (1), 8. [17]Cong-Ying Wen, Yong-Zhong Jiang, Xi-You Li, Man Tang, Ling-Ling Wu, Jiao Hu, Dai-Wen Pang, Jing-Bin Zeng*, Efficient Enrichment and Analyses of Bacteria at Ultralow Concentration with Quick-Response Magnetic Nanospheres. ACS Appl. Mater. Interfaces 2017, 9 (11), 9416-9425. [18]Cong-Ying Wen, Jingjing Chen, Mengmeng Li, Yutong Xue, Sobia Aslam, Fazle Subhan, Rusong Zhao, Jianfeng Yu, Jingbin Zeng* and Xi Chen, Gold nanoparticles deposited on mesoporous carbon as a solid-phase sorbent with enhanced extraction capacity and selectivity for anilines. Microchimica Acta 2017, 184 (10), 3929-3936. [19]Cong-Ying Wen, Mengmeng Li, Wangbo Li, Zizhou Li, Wei Duan, Yulong Li, Jie Zhou, Xiyou Li, JingBin Zeng* Graphene deposited onto aligned zinc oxide nanorods as an efficient coating for headspace solid-phase microextraction of gasoline fractions from oil samples. J. Chromatogr. A 2017, 1530, 45-50. [20]Cong-Ying Wen* and Jia-Yi Sun, Quantitative Determination of the Carboxyl Groups on Individual Nanoparticles by Acid-Base Titrimetry. ChemistrySelect 2017, 2 (33), 10885-10888. [21]Cong-Ying Wen*, Man Tang, Jiao Hu, Ling-Ling Wu, Dai-Wen Pang, Jing-Bin Zeng, Xi-You Li, Determination of the Absolute Number Concentration of Nanoparticles and the Active Affinity Sites on Their Surfaces. Anal. Chem.2016, 88 (20), 10134-10142. [22]Cong-Ying Wen, Hai-Yan Xie, Zhi-Ling Zhang, Ling-Ling Wu, Jiao Hu, Man Tang, Min Wu and Dai-Wen Pang*, Fluorescent/Magnetic Micro/Nano-Spheres Based on Quantum Dots and/or Magnetic Nanoparticles: Preparation, Properties, and their Applications in Cancer Studies. Nanoscale 2016, 8, 12406–12429. [23]Cong-Ying Wen, Ling-Ling Wu, Zhi-Ling Zhang, Yu-Lin Liu, Shao-Zhong Wei, Jiao Hu, Man Tang, En-Ze Sun, Yi-Ping Gong, Jing Yu and Dai-Wen Pang*, Quick-Response Magnetic Nanospheres for Rapid, Efficient Capture and Sensitive Detection of Circulating Tumor Cells. ACS Nano 2014, 8 (1), 941-949. [24]Cong-Ying Wen,Jun Hu, Zhi-Ling Zhang, Zhi-Quan Tian, Guo-Ping Ou, Ya-Long Liao, Yong Li, Min Xie, Zi-Yong Sun, Dai-Wen Pang*, One-step sensitive detection of Salmonella typhimurium by coupling magnetic capture and fluorescence identification with functional nanospheres, Anal. Chem. 2013, 85, 1223−1230. [25]Jun Hu, Cong-Ying Wen(共第一), Zhi-Ling Zhang, Min Xie, Hai-Yan Xie and Dai-Wen Pang*, Optically Encoded Multifunctional Nanospheres for One-Pot Separation and Detection of Multiplex DNA Sequence, Anal.Chem.2013, 85 (24), 11929-11935. [26]温聪颖*，杜正坤，吴玲玲，磁性荧光纳米球的制备及其对细胞的识别和捕获，实验技术与管理，2018, 35 (02): 54-58. [27]温聪颖*，訾敏，张瑞巧，赵令今，磁性纳米探针的构建及其对细菌分离应用，实验室研究与探索，2021，40 (6): 11-14. [28]温聪颖，张雨，曾景斌*. 超顺磁性纳米簇捕获和分离细菌综合性实验. 实验技术与管理, 2022, 39 (4): 51-56. [29]温聪颖，李想，张瑞巧，李怡敏，周亭，曾景斌*，纳米金比色法检测乙肝病毒核酸综合性实验. 实验室研究与探索，2022，41 (6): 6-10+15. 2.专利 [1] 庞代文，温聪颖，胡军，张志凌，孙自镛，发明专利：一种灵敏简便检测细菌的方法。专利号：ZL 201210345823.9. [2] 庞代文，胡军，谢敏，温聪颖，谢海燕，张志凌，发明专利：一种荧光-磁性双编码微球的制备方法。专利号：ZL 201010266616.5. [3] 曾景斌，梁鹏辉，温聪颖，一种基于Ag@Au纳米粒子的新冠病毒抗体检测方法，申请(专利)号：ZL202111435802.1. [4] 曾景斌，赵田雨，张雨，温聪颖，刘宏玉，崔淑华，唐仕明，崔炳文，基于Au-Fe3O4纳米材料的沙门氏菌识别免疫探针的制备方法及其应用，申请(专利)号：ZL 202111078082.8. | ||||||
◎代表性著作 | ||||||
[1] [2] | ||||||
◎获奖情况及荣誉称号 | ||||||
[1] 2022年，青岛市分析测试学会2021年度科学技术奖（QDAIA）一等奖，光/磁纳米材料的制备及其在生物医学检测中的应用研究，青岛市分析测试学会, 位次：1/6; [2] 2015年，湖北省优秀博士论文奖, 湖北省人民政府学位委员会, 位次：1/1; [3] 2024年，青岛市自然科学奖二等奖，光/磁异质纳米材料的精准合成及传感研究，青岛市人民政府，位次：2/5; [4] 2023年，全国服务业科技创新奖一等奖，面向典型环境毒物高效分离分析的关键技术及应用，中国商业联合会，位次：3/11； [5] 2022年，第八届山东省“互联网+”大学生创新创业大赛优秀创新创业导师, 山东省教育厅，位次：2/2； [6] 2016年，获评青岛西海岸新区区外引进高层次人才，位次：1/1； [7] 2016年，中国分析测试协会科学技术奖（CAIA奖）二等奖, 中国分析测试协会, 位次：6/10。 | ||||||
◎执教课程 | ||||||
本科生：《仪器分析》《仪器分析实验》《分析化学实验》等课程 研究生：《现代分析技术》等课程 | ||||||
◎招收及指导研究生情况 | ||||||
1. 指导研究生情况 指导学术研究生6名。 3. 招生专业及要求 化学，分析化学，生物及医学检测 | ||||||
◎学术兼职 | ||||||
[1] Biomedical Analysis青年编委； [2]ACS Nano、Biosensors & Bioelectronics、Analytical Chemistry、Chemical Engineering Journal等国际知名期刊的审稿人。 | ||||||
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